Vapes VS. Cigarettes, Which One Is Safer? E cigarettes contain hazardous substances, addictive and harmful Don't be foolede cigs or vapes may be less harmful than cigarettes, but less harmful doesn't mean safe. Vapes can contain harmful substances including nicotine, heavy metals like lead, volatile organic compounds and About E Cigarettes (Vapes) Smoking and Tobacco Use CDC Is Vaping Safer than Smoking? New Directions for Women