Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Stopping GLP 1s: Weight Regain and Maintenance Tips Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol Liver Damage & Disease GWC Law A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health