Black Lesion on the Tongue ORAL MELANOSIS leading to the diagnosis of HIV infection. Despite being a weak association, any unexplained oral pigmentation in a high risk individual should make one suspect HIV associated oral melanosis and proceed Cancer patient's tongue turned black and hairy 'after rare antibiotics reaction' The Independent Can a black pigmented lesion of the oral cavity : Journal of Family Medicine and Primary Care case 348 what's black hairy tongue? lingua villosa Nigra, tetracycline, melanosis, leucoplakia ,navi