Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Sex differences in glutathione metabolism and acetaminophen toxicity ACETAMINOPHEN INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE The Journal of Pharmacology and Experimental Therapeutics