Melanotic Macule Lip Removal TikTok This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Oral melanoma and other pigmentations: when to biopsy? Lambertini 2018 Journal of the European Academy of Dermatology and Venereology Wiley Online Library