Can You Donate Blood If You Are A Smoker? Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. you can chose vaping or a nicotine pouch, what do you choose? We all know smoking and vaping isn't great for your health. But it doesn't stop you from being a blood or plasma donor. Just make sure to wait one hour after donating Vaping, Venous Valves, and Vein Disease